Looking for a way to soften rough, calloused hands? Here are a few essential hand-care tips from beauty experts: (1) Lotion up! If you're confused about which type of hand cream you should use, stick with lotions. They're light and effective at breaking down dead skin and won't leave your hands feeling greasy. (2) Choose products with ingredients that will break down dead skin cells while allowing moisture to reach down through thickened skin. (3) Do a peel 2-3 times a week. (4) Try a nightly hand soak to calm and soften skin. (5) Always apply hand lotion before bed.