Pigmentation refers to the coloring or pigment of the skin created in cells called melanocytes. These cells produce different pigments, one of which is melanin. When the melanocytes become damaged or unhealthy, melanin production accelerates, causing hyperpigmentation. The top three skin pigmentation conditions seen by dermatologists are melasma, post-acne marks, and solar lentigines. If you want to treat irregular pigmentation issues, professional help and long-term topical skincare are the way to go.